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What is a system suitability test?

  • A.A validation of the method's accuracy and precision
  • B.A calibration of the detector's wavelength scale
  • C.A test of the pump's maximum pressure capability
  • D.A check that the whole system performs before samples run

Answer: D

Injecting a standard and checking the plate number, tailing factor, resolution and repeatability confirms that column, instrument and eluent are together fit to run the batch today. Validation is done once for the method, and wavelength and pressure checks are instrument qualification. Testing the whole system on the day, rather than trusting a validation performed months earlier, is what catches a degraded column before a batch is wasted. Reading the definition literally, rather than recalling a formula, is the reliable route through questions of this shape.

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