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What is a monolith's principal advantage?

  • A.Very low back pressure at high flow rates
  • B.Much higher efficiency than any packed bed
  • C.Complete freedom from silanol interactions
  • D.A far greater sample capacity than particles

Answer: A

The large through-pores let a monolith be run at several millilitres a minute where a packed column would exceed the pump's limit, so a separation can be made much faster. Efficiency is comparable rather than superior, silanols remain, and capacity is lower. Buying speed through a structural change rather than through pressure is the alternative route to the same end, and it suits an instrument that cannot reach high pressure.

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