Discussion
Why does ion pairing suit mass spectrometry poorly?
Answer: C
A non-volatile ion-pairing reagent competes for charge in the electrospray droplet and contaminates the source, so the analyte's signal falls sharply. Absorbance is an issue for an optical detector rather than a spectrometer, viscosity is unremarkable, and no reaction occurs. That an additive solving a chromatographic problem creates a detection one is exactly the coupling between the two halves of a hyphenated method that has to be thought through in advance.
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