Discussion
What does selected reaction monitoring achieve?
Answer: C
Watching one precursor and one specific fragment means a signal is recorded only when both match, which rejects almost all interference and gives exceptional selectivity. It records no full spectrum and cannot identify an unknown, since both masses must be chosen in advance. Trading the ability to see everything for near-immunity to interference is the right trade in routine quantitation and the wrong one in discovery. Working one numerical case through both cases side by side fixes the distinction better than any rule of thumb.
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