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Why is a chromatograph often coupled to a mass spectrometer?

  • A.The spectrometer improves the chromatographic resolution
  • B.The chromatograph provides the vacuum the spectrometer needs
  • C.The combination halves the analysis time required
  • D.The chromatograph separates what the spectrometer identifies

Answer: D

A mixture gives a superposed spectrum that is difficult to interpret, so separating the components in time and taking a spectrum of each as it elutes solves both problems at once. The spectrometer does nothing for the separation, supplies no vacuum, and the combination takes as long as the chromatography does. Two techniques each supplying what the other lacks is the definition of a useful hyphenation. A limit that survives making every external component ideal is an intrinsic one, and worth knowing for that reason.

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