Discussion
A female cat with a mutant phenotype was bred with a wild-type male cat. All progeny (4 males and 4 females) show the mutant phenotype. On the other hand, all progeny (4 males and 4 females) from the reciprocal cross between a mutant male and a wild-type female show the wild-type phenotype. Which of the following explain the inheritance pattern of the mutation?
Answer: C
The pattern is best explained by Mitochondrial inheritance.
When the mother is mutant, every offspring of both sexes is mutant; when only the father is mutant, every offspring is wild type. The trait follows the mother alone, which is the signature of maternal (cytoplasmic) inheritance: mitochondria pass to the offspring through the egg, while the sperm contributes essentially none.
A recessive or autosomal nuclear gene would behave the same in reciprocal crosses. An X-linked (sex-linked) gene would give different results in sons and daughters, not the same result in all eight offspring of each cross.
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