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Discussion

TCA cycle functions in

  • A.catabolic reactions
  • B.anabolic reactions
  • C.amphibolic reactions
  • D.none of these

Answer: C

Correct answer: amphibolic reactions

The TCA cycle is amphibolic: it works in both directions of metabolism. It oxidises acetyl-CoA for energy (catabolic), and its intermediates are drawn off as precursors - oxaloacetate and α-ketoglutarate for amino acids, succinyl-CoA for porphyrins (anabolic). Anaplerotic reactions exist precisely to replace what is withdrawn.

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