Discussion
Diagnostic DNA probes have been developed for
Answer: D
Correct answer: all of the above
Diagnostic DNA probes exist for all three pathogens. A probe is a labelled nucleic acid fragment complementary to a sequence unique to the organism, and hybridisation reports its presence directly, without the need to culture it.
This matters most where culture is slow, hazardous or impossible: Mycobacterium tuberculosis takes weeks to grow, while hepatitis B virus and the human immunodeficiency virus cannot be cultured routinely at all. Probe and amplification methods give an answer in hours and can also identify the strain or the resistance genotype.
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