Discussion
Penicillin resistance in staphylococci is acquired due to
Answer: D
Correct answer: transduction
Penicillin resistance in staphylococci is classically acquired by transduction. The penicillinase gene lies on a plasmid, and staphylococcal phages package that plasmid and carry it into new cells, which is the principal route by which the resistance spread through hospital strains.
Staphylococci have no efficient natural conjugation or transformation system comparable with that of the enteric bacteria, so those routes are not the usual explanation. Mutation can alter a chromosomal target, but the beta-lactamase responsible here is an acquired plasmid-borne enzyme rather than a mutated host gene.
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