Discussion
Classically, prions are recognized as agent causing :
Answer: D
Prions are classically known as the cause of Madcow disease, bovine spongiform encephalopathy (BSE).
Prions are misfolded forms of the normal prion protein PrP. The misfolded form (PrPSc), rich in beta sheet, converts normal PrP into more of itself, and the aggregates destroy brain tissue, leaving it sponge-like. BSE in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease and kuru in humans are the classic transmissible spongiform encephalopathies.
Schizophrenia is a psychiatric disorder with no infectious agent, and a stroke is caused by blocked or ruptured blood vessels. Alzheimer's disease does involve misfolded amyloid-beta and tau, and these are sometimes described as prion-like, but it is not transmissible and is not the classic prion disease.
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