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The citric acid cycle takes place in the

  • A.intermembrane space
  • B.cytosol of the cell
  • C.mitochondrial matrix
  • D.inner membrane itself

Answer: C

Its enzymes are dissolved in the matrix, whereas the electron transport chain is embedded in the inner membrane beside them. Glycolysis, by contrast, happens in the cytosol before pyruvate ever reaches the mitochondrion. The three stages are thus spread across two separate compartments.

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