Discussion
Chemiosmosis, as proposed by Peter Mitchell, explains ATP synthesis as being driven by
Answer: B
Correct answer: a proton gradient across a membrane
Mitchell’s proposal was that the respiratory chain pumps protons out of the matrix, and that the electrochemical gradient so created - not any chemical intermediate - drives ATP synthesis as protons flow back through the ATP synthase. It was resisted for years because it required a *membrane* to be the coupling device rather than a molecule, and it earned the Nobel Prize in 1978.
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