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Non-disjunction is the failure of

  • A.the cell to replicate its own DNA during S phase
  • B.cytokinesis to divide the cytoplasm between daughters
  • C.chromosomes or chromatids to separate properly
  • D.the nuclear envelope to break down at all

Answer: C

It can happen in either meiotic division and leaves a gamete with an extra chromosome or one too few. Trisomy 21 arises this way and becomes more likely with maternal age. Eggs arrested for decades appear to segregate less reliably over time.

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