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What will be the radioactivity of 125I labelled 2 mCi thyroxine after 4 generations (t½ = 60 days) :

  • A.0.25 mCi
  • B.0.125 mCi
  • C.0.125 µCi
  • D.1 mCi

Answer: B

The remaining activity is 0.125 mCi.

'4 generations' here means four half-lives (4 × 60 = 240 days). Each half-life halves the activity:

\[ \begin{aligned} A &= A_0 \left(\tfrac{1}{2}\right)^{4} \\ &= 2 \times \tfrac{1}{16} = 0.125\ \text{mCi} \end{aligned} \]

0.25 mCi is the value after three half-lives and 1 mCi after only one. 0.125 µCi has the right number but the wrong unit, a thousand times too small.

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