Discussion
Which of the following is the correct set of Lipinski’s rules that helps in predicting poor absorption of a drug molecule in human physiological system ?
Answer: B
The correct set is (i) molecular weight greater than 500 and (ii) number of hydrogen bonds greater than 5.
Lipinski's rule of five states that poor absorption or permeation is more likely when a molecule has a molecular weight over 500, more than 5 hydrogen-bond donors, more than 10 hydrogen-bond acceptors, or a calculated log P over 5. The paper's 'number of hydrogen bonds' refers to the hydrogen-bond donors.
Large, heavily hydrogen-bonding molecules cross membranes poorly, so both limits are 'greater than'. The options with 'less than' describe molecules that pass Lipinski's test, which predicts good absorption, not poor.
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