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What advantage does a cryogenically cooled probe offer?

  • A.Faster relaxation and so shorter experiments
  • B.Lower electronic noise and so higher sensitivity
  • C.A stronger magnetic field at the sample
  • D.A wider chemical shift range for carbon

Answer: B

Cooling the receiver coil and preamplifier to around twenty kelvin cuts their thermal noise and gives a signal to noise gain of three to four times, which is equivalent to running ten to sixteen times as many scans. The sample itself stays at its own temperature. Field is set by the magnet, shift range by shielding, and relaxation by the molecule. For a scarce natural product a cryoprobe often turns an impossible experiment into an overnight one.

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