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What is the chief limitation of NMR compared with mass spectrometry?

  • A.A far narrower range of compounds it can examine
  • B.Much lower sensitivity
  • C.Inability to distinguish isomers
  • D.Destruction of the sample during measurement

Answer: B

NMR needs micrograms to milligrams where mass spectrometry works on picograms, so its sensitivity is its weak point, a direct consequence of the tiny Boltzmann excess. Against that it distinguishes isomers superbly, which mass spectrometry often cannot, it is non-destructive so the sample is recovered, and it examines an enormous range of compounds. The two techniques are complementary rather than competing, and coupling them, as in LC-NMR-MS, exploits the strengths of each.

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