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The linkage formed between 5' and 3' carbon atoms of the pentose sugar in nucleotides is

  • A.glycosidic
  • B.phosphomonoester
  • C.amide
  • D.peptide
  • E.phosphodiester

Answer: E

The linkage is a phosphodiester linkage.

In a nucleic acid chain, a phosphate group joins the 5' carbon of one nucleotide's pentose sugar to the 3' carbon of the next. Because the phosphate is esterified to two sugar hydroxyl groups, the link is a phosphodiester, and these bonds form the sugar-phosphate backbone.

The glycosidic linkage joins the base to the 1' carbon of the sugar. A phosphomonoester is a phosphate attached to only one sugar, as at the end of a chain. Amide and peptide bonds join amino acids in proteins, not nucleotides.

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