Discussion
The end product of adenosine monophosphate (AMP) and guanosine monophosphate (GMP) catabolism in normal humans is :
Answer: D
The end product of AMP and GMP catabolism in humans is uric acid.
Both purine nucleotides are broken down to free bases and then to xanthine: AMP via inosine and hypoxanthine, GMP via guanosine and guanine. Xanthine oxidase then oxidises xanthine to uric acid, which humans excrete because, like other higher primates, they lack urate oxidase (uricase).
Xanthine is an intermediate, not the end product. Urea is the end product of amino acid nitrogen through the urea cycle, and creatinine comes from creatine phosphate in muscle. Excess uric acid is what crystallises in gout.
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