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The histone octamer at the core of a nucleosome contains two copies each of

  • A.H2A, H2B, H3 and H4
  • B.H1, H2A, H2B and H3
  • C.H1, H3, H4 and H5
  • D.H2A, H2B, H3 and H1

Answer: A

Histone H1 is the linker histone and sits outside the core, binding where the DNA enters and leaves. Confusing it with a core histone is a common error. The octamer is two copies each of four different histones, not eight different ones.

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