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If a nucleosome holds about 147 base pairs and linkers average about 53, roughly how many nucleosomes occupy 20,000 base pairs?

  • A.50
  • B.100
  • C.136
  • D.377

Answer: B

Each repeat covers about 200 base pairs once the linker is included, and 20,000 divided by 200 gives 100. Using the 147 alone would overcount, since the linker DNA also has to be accommodated. The repeat length varies somewhat between cell types and organisms.

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