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Histones bind DNA tightly chiefly because they are

  • A.entirely hydrophobic in character
  • B.bound covalently to the sugar backbone
  • C.rich in positively charged amino acids
  • D.rich in negatively charged amino acids

Answer: C

Lysine and arginine give the histones a strong positive charge that attracts the negatively charged phosphate backbone. The interaction is electrostatic and reversible rather than covalent. Chemical modification of those residues is how the grip is adjusted.

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