Discussion
State whether the following is true or false.
Histones are covalently bonded to DNA within the nucleosome.
Answer: D
The association is electrostatic, between positively charged residues and the phosphate backbone, which is why it can be loosened and re-formed. A covalent bond would make the packaging impossible to undo. Reversibility is essential, since the DNA must be unwrapped to be read or copied.
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