Discussion
Assertion (A): Histone acetylation makes a region of chromatin more accessible.
Reason (R): The acetyl group removes a positive charge that helped bind the DNA.
Answer: D
Correct answer: Both A and R are true, and R is the correct explanation of A
Both are true and the reason gives the mechanism. Histone tails are rich in lysine, whose positive charge binds the negatively charged phosphate backbone of the DNA. Acetylation neutralises that charge, loosening the grip and opening the chromatin to transcription factors - which is why histone acetyltransferases act as coactivators and deacetylases as repressors, and why deacetylase inhibitors are used as anticancer drugs.
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