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DNA methylation at promoter regions is usually associated with

  • A.silencing of the affected gene
  • B.increased transcription of the gene
  • C.physical breakage of the chromosome
  • D.duplication of the gene sequence

Answer: A

Methyl groups added to cytosine recruit proteins that compact the chromatin and block transcription. The pattern is copied when DNA replicates, so the silenced state is inherited by daughter cells. Silencing can therefore persist through many rounds of division.

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