Discussion
Consider the following statements about chromatin modification.
1. Histone acetylation is generally associated with active transcription.
2. DNA methylation at a promoter is generally associated with silencing.
3. Both modifications permanently alter the DNA sequence.
Answer: C
The first two describe the usual associations correctly. The third is wrong, since neither changes any base in the sequence, which is what distinguishes an epigenetic mark from a mutation. One changes how the text is read, the other changes the text itself.
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