Discussion
Which of the following biochemical parameter indicates chronic renal failure ?
Answer: D
Chronic renal failure is indicated by increased blood urea nitrogen.
When the kidneys fail, the glomerular filtration rate falls and nitrogenous wastes such as urea and creatinine are retained in the blood. A rising blood urea nitrogen (BUN), together with rising serum creatinine, is the classic biochemical sign.
Creatinine excretion falls, not rises, as filtration fails, so the first option is backwards. Serum albumin usually falls in kidney disease because protein is lost in the urine, and serum transferrin also tends to be low, so neither increase points to renal failure.
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