Discussion
The anaemia due to deficiency of folate is called as ......................
Answer: B
Folate deficiency causes megaloblastic anaemia.
Folate is needed for DNA synthesis. Without it, red cell precursors in the marrow cannot divide normally, so they grow into large, immature megaloblasts and the blood carries fewer, larger red cells (a macrocytic picture).
Pernicious anaemia is also megaloblastic, but the name is reserved for vitamin B12 deficiency caused by lack of intrinsic factor. Hypochromic anaemia, with pale small cells, is the picture of iron deficiency. Haemolytic anaemia comes from destruction of red cells, not from a nutrient shortage.
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