Discussion
Cyanide or azide used in poisoning, irreversibly bind to ................... that acts as a critical link between aerobic respiration and oxygen.
Answer: D
Cyanide and azide bind to Cytochrome C Oxidase.
Cytochrome c oxidase (complex IV) is the last enzyme of the respiratory chain; it passes electrons to molecular oxygen, reducing it to water. Cyanide and azide bind to the iron of its haem a3, the site where oxygen binds, and so stop electron flow and aerobic ATP production.
Succinate dehydrogenase (complex II) and NADH dehydrogenase (complex I) feed electrons into the chain, and coenzyme Q carries them to complex III; none of them reacts with oxygen. Their inhibitors are different, such as malonate for complex II and rotenone for complex I.
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