Discussion
Ring system present in methotrexate :
Answer: C
The ring system the key accepts is pyrimidine.
Methotrexate contains a pteridine nucleus (2,4-diaminopteridine) joined through p-aminobenzoic acid to glutamic acid. Pteridine is a fused bicyclic system of a pyrimidine ring and a pyrazine ring, so of the options given, pyrimidine is the ring present.
Purine, which is pyrimidine fused with imidazole, is the nucleus of 6-mercaptopurine and the other purine antagonists, not of methotrexate. Pyridine has a single nitrogen, and imidazole is a five-membered ring; neither is in methotrexate's nucleus.
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