Discussion
What is Paget's disease characterized by ? (Choose the most appropriate option from below)
Answer: B
The answer is Faulty calcium metabolism causing decalcification, bone softening and deformity.
Paget's disease of bone (osteitis deformans) is a disorder of bone remodelling. Overactive osteoclasts resorb bone, and new bone is then laid down in a disorganised way, so the bones become enlarged, weakened and deformed, typically the skull, spine, pelvis and legs. The key's wording, a defect of calcium metabolism with decalcification, softening and deformity, is the textbook description used in pharmacy courses, where calcitonin and bisphosphonates are its treatment.
Faulty iron metabolism causes anaemia, vitamin C deficiency causes scurvy, and vitamin D deficiency causes rickets in children. None of these is Paget's disease.
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