Discussion
Drug level should be monitored in the treatment of which disease ?
Answer: C
Drug levels should be monitored in the treatment of epilepsy.
Several antiepileptics, phenytoin above all, have a narrow therapeutic range, wide variation between patients and, for phenytoin, saturation (zero-order) kinetics, so a small dose change can cause toxicity. Their effect is also hard to judge clinically, since the aim is the absence of seizures, so plasma levels are measured to guide the dose.
In hypertension and diabetes the effect is measured directly as blood pressure and blood glucose, so drug levels are not needed. In asthma, levels matter only for theophylline, which is now little used, not for the inhalers that make up most treatment.
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