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Vaccinia virus is now used chiefly as

  • A.a laboratory contaminant
  • B.the cause of monkeypox
  • C.a vaccine vector
  • D.a natural human pathogen of the skin

Answer: C

Correct answer: a vaccine vector

Vaccinia was the virus used to vaccinate against smallpox, and with smallpox gone that purpose disappeared. What survives is its usefulness as a delivery system: its large genome tolerates the insertion of foreign genes, it replicates in the cytoplasm, and it provokes a strong immune response, so a recombinant vaccinia can present antigens from quite unrelated pathogens to the immune system.

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