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A vaccine against hepatitis A is practical largely because the virus has

  • A.a double-stranded DNA genome
  • B.an envelope carrying spikes
  • C.a single serotype
  • D.115 serotypes

Answer: C

Correct answer: a single serotype

A vaccine works by raising antibody against the antigens of the strain it contains, so a virus with many serotypes needs a vaccine with many components, or none at all. Hepatitis A has exactly one worldwide, so a single inactivated preparation protects against every isolate, and immunity is durable. That is why an effective hepatitis A vaccine exists and a common cold vaccine does not.

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