Discussion
Ubiquitin ligases are associated with degradation of :
Answer: A
Ubiquitin ligases are associated with degradation of Protein.
Ubiquitin is attached to target proteins in three steps: E1 activates it, E2 carries it, and the E3 ubiquitin ligase recognises the specific substrate and transfers ubiquitin to a lysine on it. A chain of four or more ubiquitins linked through lysine 48 marks the protein for destruction by the 26S proteasome. This pathway removes cyclins, misfolded proteins and many regulators (Nobel Prize in Chemistry, 2004).
DNA is broken down by nucleases, RNA by ribonucleases and the exosome, and carbohydrates by glycosidases. None of these depends on ubiquitin tagging.
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