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Which of the following component binds to protein and guides for its degradation ?

  • A.Ubiquitin
  • B.Methylation
  • C.Acetylation
  • D.Phosphorylation

Answer: A

The component is ubiquitin.

Ubiquitin is a small 76-amino-acid protein. A cascade of E1, E2 and E3 enzymes attaches it to lysine residues of the target, and a chain of ubiquitins marks the protein for destruction by the 26S proteasome.

Methylation, acetylation and phosphorylation are chemical modifications, not components that bind proteins. They regulate activity, chromatin structure and signalling; they can influence stability indirectly, but none is the tag that guides a protein to degradation.

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