Discussion
Which one of the following closely defines 'Molten Globule' state of a protein?
Answer: A
A molten globule is a state with high degree of secondary structure and loss of tertiary structure.
The molten globule is a compact, partly folded intermediate seen during protein folding and under mildly denaturing conditions such as low pH. Most of the native helices and sheets are already formed, but the tight, specific packing of side chains that makes up the tertiary structure is missing, so the core is loose and 'molten'.
A complete loss of secondary structure, or a completely unfolded chain, describes the random coil, which is the opposite. Loss of quaternary structure concerns subunits coming apart and can happen in a fully folded monomer; it does not define the molten globule.
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