Discussion
Mutation in gene rel A in bacteria results in .................... .
Answer: A
Mutation in relA gives relaxed mutants.
The RelA protein makes the alarmone ppGpp when ribosomes stall for lack of charged tRNA during amino acid starvation. ppGpp shuts down rRNA and tRNA synthesis, the stringent response. In relA mutants no ppGpp is made, so stable RNA synthesis continues despite starvation; such mutants are called relaxed.
Silent mutations change no amino acid, constitutive mutants express genes regardless of conditions, and dominance describes allele interaction. None describes the loss of the stringent response.
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