Discussion
In the Fischer projection, the absolute configuration of a chiral centre will not change from R to S when,
Answer: C
The configuration does not change when the priority numbers 1 and 2 are interchanged and then 3 and 4 are interchanged.
In a Fischer projection, swapping any two groups on the stereocentre inverts its configuration (R becomes S). Two such swaps invert it twice, which restores the original configuration.
Options A, B and D each describe a single interchange, so each of them changes R to S.
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