Discussion
Cell wall protein of Streptococcus pyogenes crossreacts with human
Answer: C
Correct answer: myocardium
The M protein, the chief cell wall protein and the principal virulence factor, shares epitopes with cardiac muscle, so antibody directed against it also attacks the myocardium. Together with the cell wall carbohydrate’s cross-reaction with the valves, this accounts for the pancarditis of rheumatic fever - two different bacterial antigens attacking two different cardiac tissues.
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