Discussion
Which of the following bacteria is most resistant to the drug vancomycin?
Answer: A
Correct answer: Enterococcus faecium
Vancomycin resistance is far commoner in E. faecium than in E. faecalis, and vancomycin-resistant E. faecium is one of the principal hospital-acquired resistance problems. The resistance comes from van gene clusters that replace the terminal D-alanine of the cell wall precursor, so vancomycin can no longer bind.
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