Discussion
Which of the following immunity is protective against infection by S.pyogenes?
Answer: A
Correct answer: humoral immunity
Protection against S. pyogenes is antibody-mediated and directed against the M protein, and it is type specific: antibody to one M type protects against that type alone, which is why repeated infections with different types are possible throughout life. The type specificity is also the chief obstacle to a vaccine, since there are more than a hundred M types.
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