Discussion
Consider the following statements about aerobic fermentation.
1. Oxygen transfer is often the limiting factor at large scale.
2. Agitation and sparging are used to raise the transfer rate.
3. Scale-up is simply a matter of increasing the vessel volume.
Answer: B
The first two are correct. The third is exactly the difficulty, since oxygen transfer per unit volume falls as the vessel grows and the power input must rise sharply to compensate. Vessel geometry is chosen with this in mind.
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