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When you are continuously exposed to specific antigen for a longer period which of the following statements falls wrong ?

  • A.There will be antibody class switching happening in the body
  • B.There will be affinity maturation happening in the body
  • C.The body produces same antibody always
  • D.There will be primary and secondary response happening

Answer: C

The wrong statement is The body produces same antibody always.

Repeated or prolonged exposure to an antigen changes the antibody response. Activated B cells switch class from IgM to IgG, IgA or IgE, and somatic hypermutation followed by selection in germinal centres raises the affinity of the antibodies (affinity maturation). The first encounter gives a slower primary response dominated by IgM, and later encounters a faster, larger secondary response dominated by IgG.

The other three statements describe exactly these changes, so they are correct. Only the claim that the same antibody is made throughout contradicts them.

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