Discussion
Chloramphenicol inhibits protein synthesis by acting on which target ?
Answer: B
Correct answer: The 50S subunit, inhibiting peptidyl transferase
Chloramphenicol binds the 50S subunit and blocks the peptidyl transferase centre, so no peptide bond forms. It is bacteriostatic, and because mitochondrial ribosomes are also 70S it carries a risk of bone marrow toxicity.
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