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Discussion

Catabolite repression of the lac operon is relieved by the binding of ________.

  • A.the repressor to the operator
  • B.the CAP-cAMP complex to the promoter region
  • C.glucose to the permease
  • D.tryptophan to the leader sequence

Answer: C

Correct answer: the CAP-cAMP complex to the promoter region

When glucose is scarce, cAMP rises and the catabolite activator protein binds it. The CAP-cAMP complex then binds near the promoter and helps recruit RNA polymerase, which is why the operon is fully expressed only when glucose is absent and lactose present.

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