Discussion
Which of the following toxin resembles cholera toxin?
Answer: C
Correct answer: Labile toxin of Escherichia coli
Cholera toxin and the heat-labile toxin of enterotoxigenic E. coli share the same A-B structure and the same mechanism: the B subunits bind the GM1 ganglioside, the A subunit enters and ADP-ribosylates the G protein, adenylate cyclase is locked on, and the resulting cyclic AMP drives the secretory diarrhoea. The two are so alike that antibody to one neutralises the other.
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