Discussion
Cholera toxin produces watery diarrhoea by ________.
Answer: A
Correct answer: irreversibly activating adenylate cyclase and raising cyclic AMP
The A subunit ADP-ribosylates the Gs regulatory protein, locking adenylate cyclase in the active state. The resulting flood of cyclic AMP drives chloride and water into the lumen, which is why the mucosa remains intact and the stool contains no blood or pus.
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