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A positive-sense RNA genome is one that

  • A.cannot be translated at all
  • B.can act directly as mRNA
  • C.must first be copied by a viral polymerase
  • D.is always double stranded

Answer: B

Plus-strand RNA reads as messenger RNA, so the naked genome introduced into a cell is infectious on its own: ribosomes translate it and the viral proteins follow. Poliovirus is the classic example, and its purified RNA can start an infection without any protein.

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