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Host cell RNA polymerase can be used to make viral mRNA only when

  • A.a DNA genome reaches the nucleus
  • B.the genome is single-stranded RNA
  • C.the virus is enveloped
  • D.the virus has a segmented genome

Answer: A

Cellular transcriptases sit in the nucleus and act on DNA, so only viruses whose DNA genome arrives there can use them. Every RNA virus, and every cytoplasmic DNA virus such as a poxvirus, has had to evolve or carry a transcriptase of its own.

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